Occupational diesel exposure, duration of employment, and cumulative risk of lung cancer: an application of the parametric g-formula
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Lung Cancer and Elemental Carbon Exposure in Trucking Industry Workers
BACKGROUND Diesel exhaust has been considered to be a probable lung carcinogen based on studies of occupationally exposed workers. Efforts to define lung cancer risk in these studies have been limited in part by lack of quantitative exposure estimates. OBJECTIVE We conducted a retrospective cohort study to assess lung cancer mortality risk among U.S. trucking industry workers. Elemental carbo...
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In June 2012, an IARC Monographs Working Group reevaluated the carcinogenic hazards to humans of diesel and gasoline engine exhausts, and of some nitroarenes that are found in these emissions. Diesel engine exhaust was classified as “carcinogenic to humans” (Group 1) and gasoline engine exhaust as “possibly carcinogenic to humans” (Group 2B). The most influential epidemiological studies on canc...
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متن کاملExposure-Response Estimates for Diesel Engine Exhaust and Lung Cancer Mortality Based on Data from Three Occupational Cohorts
BACKGROUND Diesel engine exhaust (DEE) has recently been classified as a known human carcinogen. OBJECTIVE We derived a meta-exposure-response curve (ERC) for DEE and lung cancer mortality and estimated lifetime excess risks (ELRs) of lung cancer mortality based on assumed occupational and environmental exposure scenarios. METHODS We conducted a meta-regression of lung cancer mortality and ...
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Objectives: To explore two different approaches to calculate average exposure in occupational cohorts using a large occupational cohort as an example. The data for occupational cohort exposed to acrylonitrile was collected and analyzed previously by NCI; outcome was lung cancer. Methods: Both approaches use cumulative exposure as the numerator. As the denominator, one uses the duration of expos...
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تاریخ انتشار 2015